中国科学院长春应用化学研究所化学生物学实验室
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刘舒
时间:2022-06-02 点击:
 
刘舒 研究员

学历:博士研究生

学科:物理化学

电话:0431-85262613

邮箱:mslab20@ciac.ac.cn

地址:吉林省长春市人民大街5625号

 
简历介绍

       198510月生于山东菏泽。中国科学院长春应用化学研究所研究员。吉林省第八批拔尖创新人才第三层次专家。20077月毕业于曲阜师范大学,获学士学位;20127月毕业于中国科学院长春应用化学研究所,获博士学位。毕业后留所工作至今。主要从事中药药效物质基础及作用机制、中药活性成分筛选方法开发、质谱新技术新方法和生物样本前处理新方法研究。先后主持国家自然科学基金项目4项(面上3项,青年1项)、国家科技重大专项重大新药创制专项子任务1项、中科院青年科技人才培养计划项目1项、省部级医药产业专项和技术创新课题3项,中科院仪器功能开发项目2项,吉林省发改委产业技术创新课题1项;主持企业中药大品种二次开发及技术创新课题7项。近年来,以第一或通讯作者在在Analytical ChemistryAnalytica Chimica ActaTalanta等国际学术期刊发表SCI论文60余篇,授权发明专利14项。获吉林省科技进步一等奖2项,吉林省科技进步二等奖1项,中国中西医结合学会科学技术二等奖1项,吉林省自然科学学术成果二等奖1项。应邀担任Journal of Pharmaceutical Analysis、《中草药》等期刊青年编委。

代表性成果

代表论文:

1. Ningning Zhao, Zhiqiang Liu, Junpeng Xing, Zhong Zheng, Fengrui Song, Shu Liu*. Teamed boronate affinity-functionalized branched polyethyleneimine-modified magnetic nanoparticles for the selective capture of ginsenosides from rat plasma, Chemical Engineering Journal, 2020, 383: 123079

2. Ningning Zhao, Qianqian Gu, Zhiqiang Liu, Fengrui Song, Zifeng Pi, Shu Liu*. An integrated platform for a high-throughput pharmacokinetic study of glycosides using a boronic acid-functionalized 96-well glass plate, Chemical Communications, 2019, 55(64): 9543-9546

3. Ningning Zhao, Tiantian Zhao, Meiling Fan, Zhiqiang Liu, Zifeng Pi, Fengrui Song, Junpeng Xing, Shu Liu*. Stable isotope labeling derivatization combined with multiple-mass spectrometry technologies to monitor metabolites of tenuifoliside A incubated with intestinal bacteriaincubation model, Talanta, 2021, 224: 121791

4. Yan Zheng, Zhiqiang Liu, Junpeng Xing, Zhong Zheng, Zifeng Pi, Fengrui Song, Shu Liu*. In situ analysis of single cell and biological samples with rGO-Cu functional probe ESI-MS spectrometry, Talanta, 2020, 211(211): 120751

5. Guorong Cheng, Zifeng Pi, Zhong Zheng, Shu Liu*, Zhiqiang Liu, Fengrui Song*. Magnetic nanoparticles-based lactate dehydrogenase microreactor as a drug discovery tool for rapid screening inhibitors from natural products, Talanta, 2020, 209: 0-120554

6. Guifang Feng, Zhiqiang Liu, Shu Liu*, Junpeng Xing, Fengrui Song, Zifeng Pi. A target integration strategy for analyzing multidimensional chemical and metabolic substance groups ofDing-Zhi-Xiao-Wan prescription by using ultra-high performance liquid chromatography tandem massspectrometry, Journal of Chromatography A, 2019, 1608: 460412

7. Guifang Feng, Yan Zheng, Yufei Sun, Shu Liu*, Zifeng Pi, Fengrui Song, Zhiqiang Liu*. A targeted strategy for analyzing untargeted mass spectral data to identify lanostane-type triterpene acids in Poria cocos by integrating a scientific information system and liquid chromatography-tandem mass spectrometry combined with ion mobility spectrometry, Analytica Chimica Acta, 2018, 1033: 87-99

8. Guifang Feng, Yufei Sun, Shu Liu*, Fengrui Song, Zifeng Pi, Zhiqiang Liu*. Stepwise targeted matching strategy from in vitro to in vivo based on ultra-high performance liquid chromatography tandem mass spectrometry technology to quickly identify and screen pharmacodynamic constituents, Talanta, 2019, 194: 619-626

9. Guifang Feng, Shizhe Li, Shu Liu*, Fengrui Song, Zifeng Pi, Zhiqiang Liu*. Targeted screening approach to systematically identify the absorbed effect substances of poria cocos in vivo using ultrahigh performance liquid chromatography tandem mass spectrometry, Journal of Agricultural and Food Chemistry, 2018, 66(31): 8319-8327

10. Yan Zheng, Shu Liu*, Junpeng Xing, Zhong Zheng, Zifeng Pi, Fengrui Song, Zhiqiang Liu*. Equivalently quantitative ion strategy with quaternary ammonium cation derivatization for highly sensitive quantification of lanostane-type triterpene acids without standards by ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS), Analytical Chemistry, 2018, 90(23): 13946-13952
 
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地址:吉林省长春市人民大街5625号 邮编:130022 电话:0431-85262656
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