曲晓刚课题组李稳文章被 Adv. Mater. 接收,文章发表在Adv. Mater. 2013, 25, 6737–6743上。
We have successfully fabricated a 3D graphene oxide hydrogel as an active cell scaffold. The hydrogel can efficiently capture cells not only through the bioadhesive ligand RGD but can also release the cells on demand on application of an NIR light stimulus, which can realize better dynamic control on cells than traditional passive cell depots. In the fi rst example, GO was used as both the biocompatible scaffold and the NIRlight responsive smart element to trigger an “on–off” switch on the morphology and function of the hydrogel for dynamic control of cell release. NIR light not only allows spatial and temporal control over cells in a non-contact mode but also circumvents poor tissue penetration and the detrimental side-effects of UV light. The current study is focused on the capability of active scaffold for NIR controlled cell release, and it can further develop into the multifunctional scaffold for controlled delivery of various therapeutic biological agents and multiple cell types.This work may promote design and construction of NIR-triggeredreversible platform for cell preservation, therapeutic cell delivery, and disease-related cell isolation and analysis.