曲晓刚课题组李蒙文章被 Adv. Mater. 接收,文章发表在 Adv. Mater. 2012, 24, 1722–1728 上。
Our design combines the unique high NIR absorption property of GO with a clinically used A β fibril staining dye, ThS. Although reduced GO exhibits a higher NIR absorption than non-reduced GO, we chose non-reduced GO to performthe experiment in consideration of the high stability and dissolubility of non-reduced GO in biomedium, especially in complex cerebrospinal fl uid. Compared with traditional drug strategies, the functional GO can cross the blood–brain barrier (BBB) which overcomes the drawbacks of unstable small chemicals or peptides. Furthermore, the hyperthermic effects of GO have been considered important and useful in clinical treatment with reduced side effects. So far, there is no report of the use of multi functional GO for photothermal treatment of AD. The synthesized GO–ThS can effectively dissociate amyloid deposits both in buffer and in mice CSF, and protect cells from A β -related toxicity upon NIR irradiation. In addition, the disaggregation of A β fibrils can be monitored by the fl uorescence change of the A β fi bril staining dye, ThS. Therefore, our results could provide new insights into the design of new multifunctional GO systems for the photothermal treatment of AD.