曲晓刚课题组冯凌燕文章被 Adv. Mater. 接收，文章发表在 Adv. Mater. 2012, 24, 125–131 上。

    Gyclin A2 has been a prognostic indicator in early-stage cancers, but until now the detection of cyclin A2 in cancer cells has not yet been realized. Based on porphyrin functionalized graphene-modified electrode, we have constructed an electrochemical impedance peptide sensor for label-free detection of cyclin A2. This electrochemical sensor cannot only detect cyclin A2 in cancer cell extracts but also differentiate cancer cells from normal ones. The main possible reasons for the improved sensitive detection for cyclin A2 can be: 1) the method we used, the EIS method is label-free and highly sensitive to minor changes on the electrode surface; 2) noncovalent-functionalized TCPP/CCG nanocomposite contains the instinct conductivity of graphene and brings more–COOH groups for the following immobility of peptide; 3) site-specific cyclin A2 binding P0 and Tween 20 are used as the nanoscale anchorage substrate to capture target protein and avoid nonspecific binding (NSB) that can further improve sensor sensitivity and selectivity. Besides, the constructed graphene surface shows no obvious cytotoxicity under our experimental conditions and provides the possibility for further biomedical applications or construction of other apparatus with biocompatibility.