曲晓刚课题组赵传奇同学文章被 J. Am. Chem. Soc.接收，文章发表在 J. Am. Chem. Soc., J. Am. Chem. Soc. 2013, 135, 18786-18789上。

  Long human telomeric fragments can form stable, higher-order G-quadruplex structures, recently identified in human cells, which are potential drug targets. However, there are very few examples of ligand binding to higher-order G-quadruplexes, and all the reported ligands are proposed to bind at the cleft between two Gquadruplexes. Here we report that zinc-finger-like chiral supramolecular complexes prefer binding to higher-order G-quadruplexes over a single G-quadruplex, with ～200-fold higher selectivity. To our knowledge, this is the first example of a ligand that can distinguish higher-order Gquadruplexes from a single G-quadruplex with such high selectivity. Further studies indicate that the nanosized chiral complex would bind to two well-matched Gquadruplex units, instead of binding at the cleft between the two G-quadruplexes. These results provide new insights into the targeting of higher-order G-quadruplex ligands. Our work illustrates that dimeric G-quadruplex units can be ligand-preferred binding sites.